>Corresponsing Author : Michel Leclerc
>Article Type : Brief Report Article
>Volume : 1 | Issue : 1
>Received Date : 27 August, 2021
>Accepted Date : 9 September, 2021
>Published Date : 12 September, 2021
>DOI : http://dx.doi.org/JCCI2100102
>Citation : Leclerc M (2021) Entiere Identities Between Ophiocomina Nigra Igkappa Gene and Human Immunoglobulin Kappa Locus. New Aspects of Invertebrate Igkappa Genes (Ipa). J Clin Class Immunol 1(1): doi http://dx.doi.org/JCCI2100102
>Copyright : 2021 Leclerc M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Brief Report Article | Open Access
Immunology of Invertebrates, Biology/Biochemistry, Orleans University, France
*Corresponding author: Michel Leclerc, Immunology of Invertebrates, Biology/Biochemistry, Orleans University, France
Entire identities between Invertebrate Ophiocomina nigra IGKappa gene and Human IGK gene are confirmed, in the present work, at the level of immunoglobulin domains (constant and variable).
Keywords: IGKappa; Ophiocomina
Abbreviations: DNA: Deoxyribonucleic acid, RNA: Ribonucleic acid.
The transcriptome of the Ophuirid: Ophiocomina nigra IGKappa gene was discovered recently . Since it was synthesized de novo and cloned in a pUC-GW-Kan plasmid  which was a gift of Bo Huang laboratories. The original sequence of the IGKappa gene, after cloning, was the following in 5’-3’:
The original gene, the original protein issued from this last one share total identity with Homo sapiens immunoglobulin kappa locus, mRNA (cDNA clone MGC:22645 IMAGE:4700961): they have a complete identity (Figure1).
The Sequence of the concerned gene is ID: BC030813.1
At last, the Protein GenBank  has the following number: AAH30813.1 with 234 amino acids as shown below:
It is shown, for the first time, that an invertebrate IGKappa gene shares entiere identity with a human immunoglobulin (Fig.1)
Figure 1: IGK@ protein [Homo sapiens] graphic (in dark) by NCBI shares IG domains with Ophiocomina nigra IGKappa protein (in grey) issued from ophuirid IGKappa gene.
GenBank: AAH30813.1 protein issued from IGK gene has two immunoglobulin domains:
1. Region 1
Comment: Immunoglobulin (Ig) light chain, kappa type, Variable (V) domain
Length 105 aa
2. Region 2
Comment: Immunoglobulin constant domain
Length 100 aa